Accelerated onset of pancuronium with divided doses

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Attempted acceleration of the onset of action of pancuronium. Effects of divided doses in infants and children.

The study was designed to determine whether the onset of action of pancuronium in infants and children could be accelerated by its administration in divided doses. Sixty paediatric patients (0-1 yr (n = 20); 1-3 yr (n = 20); 3-10 yr (n = 20)) were studied during nitrous oxide-oxygen-halothane anaesthesia using train-of-four stimulation, and the results were compared with data obtained previousl...

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Divided doses of methohexitone improves ECT outcome.

To the Editor: We read with interest the recent report on substitution of mivacurium for succinylcholine for ECT treatment. ~ Since the effect of mivacurium outlasts the effect of methohexitone (MH) the authors suggested reversal of the neuromuscular block after treatment to avoid awareness. While we are unaware of a correlation between the length of seizures and the antidepressant effect of EC...

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Stability of Bevacizumab Divided in Multiple Doses for Intravitreal Injection.

OBJECTIVE To investigate the stability of bevacizumab in multiple doses divided from a single-use vial for intravitreal injection after storage at 4°C for up to six months and under drug transfer condition in tropical climate. MATERIAL AND METHOD Five syringes (0.1 mL, 2.5 mg) of bevacizumab were withdrawn each from five new bevacizumab single-use vials (4 mL, 100 mg) under sterile technique....

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Priming of pancuronium with magnesium.

Magnesium inhibits the release of acetylcholine from the motor nerve terminal and thus potentiates the action of the non-depolarizing neuromuscular blocking drugs. We have examined the possibility that this effect might enhance the speed of onset of non-depolarizing block with pancuronium. Following the administration of pancuronium 100 micrograms kg-1, 95% depression of thumb twitch occurred i...

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The Effect of Defasciculating Doses of Pancuronium and Atracurium on Succinylcholine Neuromuscular Blockade

BACKGROUND A defasciculating dose of non-depolarizing muscle relaxant administered prior succinylcholine decrease its side effects including fasciculations and postoperative myalgias; however it is believed that the dosage of succinylcholine should be increased when such a pre-treatment is used. OBJECTIVES We hypothesized that a defasciculating dose of pancuronium as a pre-treatment could pro...

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ژورنال

عنوان ژورنال: Canadian Anaesthetists’ Society Journal

سال: 1985

ISSN: 0008-2856,1496-8975

DOI: 10.1007/bf03008530